
Sweeping structural changes and scientific breakthroughs are driving
demand for new products, services and technologies

Active
Aethon, Inc. is the leading maker of practical, dependable courier robots for hospitals. The company’s proprietary, fully autonomous robots improve efficiency of hospital deliveries such as clinical supplies, pharmaceuticals, food, linen, waste and other items.
Ambit Biosciences Corp. is a biopharmaceutical company engaged in the discovery and development of small-molecule kinase inhibitors for the treatment of cancer. With more than 500 distinct kinases identified and over 30 kinase inhibitors in clinical trials or FDA approved, this important class of proteins is a rich area for therapeutic drug development.
Amicus Therapeutics, Inc. (NASDAQ:FOLD) is a biotechnology company developing small-molecule, orally-active drugs, known as Pharmacological Chaperones for treating human genetic disorders. Pharmacological chaperones are designed to help mutant proteins fold correctly into their normal 3-dimensional conformations, rescuing intrinsic biological activity and function.
Athersys, Inc. (NASDAQ:ATHX) is a biopharmaceutical company engaged in the discovery and development of therapeutic product candidates designed to extend and enhance the quality of human life. The Company is developing MultiStem, a patented, adult-derived "off-the-shelf" stem cell product platform for multiple disease indications, including damage caused by myocardial infarction, bone marrow transplantation/oncology support, ischemic stroke and other indications. The Company is also developing a portfolio of other therapeutic programs, including orally active pharmaceutical product candidates for the treatment of metabolic and central nervous system disorders.
BioStorage Technologies, Inc. is a leading provider of advanced biomaterials storage, inventory management and worldwide cold-chain logistics. The company serves pharmaceutical developers and manufacturers, non-profit and corporate clinical research facilities, donor organizations, forensic laboratories, universities, zoological and veterinarian treatment and research facilities, healthcare and life sciences companies.
Comprehensive Clinical Development, Inc.
is a strategic clinical research partner providing a full range of clinical
development services in various therapeutic areas with an outstanding record
for delivering exceptional quality and cost-effective trial management. The
company possesses expertise in multiple therapeutic areas, with a specialty
in central nervous system disorders. Comprehensive Clinical Development
delivers accelerated product development, integrated clinical trial
management and high quality research services for all phases of trials.
EndoGastric Solutions, Inc. is a medical device company and market leader in the emerging field of natural orifice translumenal endoscopic surgery, a new surgical approach that eliminates skin incisions in surgical operations on the stomach and gastrointestinal tract. The company’s endoscopic surgical devices enable incisionless, transoral procedures for the treatment of upper gastrointestinal problems, including gastroesophageal reflux disease and revision to bariatric surgery.
Health Language, Inc. is a healthcare information technology company engaged in the development and marketing of a proprietary middleware application called LE (Language Engine) that automates the incorporation of controlled medical vocabulary and coding standards into healthcare IT applications. The principal benefits of this application are substantially improved decision support systems and more efficient and accurate computerized order entry that can lead to a reduction in medical errors and improved patient safety.
Healthsense Inc. is a market leader in providing technology solutions for the future of aging services. Healthsense offers completely integrated systems based on a standard Wi-Fi platform for Personal Emergency Response Systems, nurse call and remote safety. These systems are scalable, flexible and proven across a broad base of installations. The flagship Healthsense product is the eNeighbor® system, which monitors individuals in their homes and automatically calls for help if it detects a possible problem. The eNeighbor® system utilizes a series of wireless sensors placed throughout the residence that capture the occupant's activities of daily living.
Management Health Solutions, Inc. is a full service supply chain management company specializing in physical inventory measurement, data management, and supply chain optimization services for hospitals. The Company utilizes state-of-the-art technology to create greater visibility for the clinical supplies that are purchased, used, and stored and thereby improve health care quality while reducing clinical supply costs.
NuGEN Technologies, Inc. is a life sciences research tools company developing and marketing powerful technology for efficient and cost-effective amplification of nucleic acids (DNA and RNA), a critical rate limiting step in genomics research for the identification of new drugs and drug targets.
Resolvyx Pharmaceuticals, Inc. is a biopharmaceutical company engaged in the discovery, development and commercialization of Resolvins. Resolvins are naturally-occurring, small molecule lipid mediators with the potential to treat a wide range of inflammatory diseases. Initial indications include, among others, asthma, rheumatoid arthritis, cardiovascular disease and multiple eye diseases.
Rib-X Pharmaceuticals, Inc. is a biotechnology company focused on the structure-based design of new classes of antibiotics. The company's underlying drug discovery engine capitalizes on its proprietary high-resolution crystal structure of the 50S subunit of the ribosome, which performs an essential role in the fundamental process of protein synthesis. Rib-X has multiple drug candidates in clinical and preclinical development targeting some of the leading causes of serious community and hospital-acquired infectious diseases.
U-Systems, Inc. designs, develops, manufactures and markets innovative, ultrasound systems and software to assist the radiologist in detection of breast cancer in women with dense breast tissue. The Company's first product, the Somo.v™ automatically scans the whole-breast and presents the results to the physician in a mammogram-like format - enabling high volume, cost-effective ultrasound imaging.
ZettaCore, Inc. is engaged in the research, development and manufacture of advanced molecular materials for applications in the electronics industry. The company's proprietary chemistry leverages existing semiconductor manufacturing infrastructure and enables the transition to higher performance at lower cost.
Realized
ActiveHealth Management, Inc. was acquired by Aetna Inc. in May 2005. Prior to the acquisition, ActiveHealth Management was a healthcare information technology and services company focused on improving the effectiveness of disease diagnosis and management. Key to the company's capabilities was proprietary software that integrated a wide array of clinical information with protocols and standards to elevate the quality of care in real time and reduce the overall cost for payors.
AMICAS, Inc. was acquired by VitalWorks, Inc. in November 2003. Prior to the acquisition, the company was engaged in the development and marketing of web-based Picture Archiving and Communication Systems "PACS" that provide diagnostic quality radiology image management services, including secure image capture, distribution, workflow integration and image archiving.
BEI Medical Systems Company, Inc. was acquired by Boston Scientific Corporation in June 2002. Prior to the acquisition, the company was engaged in the manufacture and marketing of a new, proprietary and minimally invasive endometrial ablation system, the Hydro ThermAblator HTA), representing a major advance in the treatment of abnormal uterine bleeding, a condition known as menorrhagia, that affects more than 10 million women in the U.S. annually. The HTA system received FDA approval and was commercially launched in 2001.
Bio-Lok International, Inc. was acquired by Healthpoint Capital in October 2006. Prior to the acquisition, the company was engaged in the manufacturing and distribution of an innovative line of dental implants and other products targeting the global oral surgery and general dentistry markets. Bio-Lok's industry-leading and FDA approved dental implant system, the Silhouette Laser-Lok™, utilizes a proprietary, laser micro-machined surface the Bio-Affinity Collar) to promote soft tissue and bone adherence while preventing epithelial down-growth - major advancements in the field of esthetic dentistry.
Clinical Micro Sensors, Inc. was acquired by Motorola in June 2000. Prior to the acquisition, the company was engaged in the development of DNA biochips aimed at enabling the delivery of valuable genetic information to biomedical researchers, physicians, and industrial users.
Conor Medsystems, Inc. was acquired by Johnson & Johnson in January 2007. Prior to the acquisition, Conor was developing, manufacturing and marketing next generation drug eluting stents. The company's initial focus was on the treatment of coronary restenosis. Conor completed an IPO in December 2004.
Corus Pharma, Inc. was acquired by Gilead Sciences in August 2006. Prior to the acquisition, Corus was developing small molecule drugs for the treatment of respiratory diseases.
Heartscape Technologies, Inc. was acquired by Roper Industries, Inc. pursuant to an asset transaction in February 2010. Prior to the acquisition, the company was engaged in the manufacture, design and commercialization of the Prime ECG System, an 80-lead ECG developed for accurate early detection of heart attack and ischemia in the emergency room setting.
Medingo Ltd. was acquired by F. Hoffman La-Roche in 2010. Prior to the acquisition, Medingo was developing next generation insulin dispensing and glucose monitoring technologies for patients with diabetes. Medingo’s initial product, The Solo™, is one of the first products in a new category of insulin pumps called "dispensing patches" that will address the shortcomings of traditional larger "pager-like" pumps.